Publications

DNA-encoded Library Screening Uncovers Potent DNMT2 Inhibitors Targeting a Cryptic Allosteric Binding Site

Frey AF, Schwan M, Weldert AC, Kadenbach V, Kopp J, Nidoieva Z, Zimmermann RA, Gleue L, Zimmer C, Jörg M, Friedland K, Helm M, Sinning I, Barthels F*. iScience 2025, accepted.

A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors

Nidoieva Z, Sabin MO, Dewald T, Weldert AC, Hoba SN, Helm M, Barthels F*. Commun Chem 2025, 8(1), 1–9.

Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole–nicotinamide chemotype

Weldert AC, Frey AF, Krone MW, Krähe F, Kuhn H, Kersten C, Barthels F*. RSC MedChem 2025, D5MD00359H.

Nanomole Scale Screening of Fluorescent RNA-Methyltransferase Probes Enables the Discovery of METTL1 Inhibitors

Meidner JL, Frey AF, Zimmermann RA, Sabin MO, Nidoieva Z, Weldert AC, Hoba SN, Krone MW, Barthels F*. Angew Chem 2024, 63(48), e202403792.

Non-covalent dyes in microscale thermophoresis for studying RNA ligand interactions and modifications

Kallert E, Behrendt M, Frey AF, Kersten, C, Barthels F*. Chem Sci 2023, 14(36), 9827–9837.

Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates

Maus H, Müller P, Meta M, Hoba SN, Hammerschmidt SJ, Zimmermann RA, Zimmer C, Fuchs N, Schirmeister T, Barthels F*. Chemistry. 2023, 29(50), e202301855.

Designing photoaffinity tool compounds for the investigation of the DENV NS2B–NS3 protease allosteric binding pocket

Maus H, Gellert A, Englert OR, Chen JX, Schirmeister T, Barthels F*. RSC Med Chem. 2023, 14(11), 2365-2379.

A low-cost 3D-printable differential scanning fluorometer for protein and RNA melting experiments

Barthels F*, Hammerschmidt SJ, Fischer TR, Zimmer C, Kallert E, Helm M, Kersten C, Schirmeister T. HardwareX, 2022, 7(11), e00256.

FINDUS: An Open-Source 3D Printable Liquid-Handling Workstation for Laboratory Automation in Life Sciences

Barthels F*, Barthels U, Schwickert M, Schirmeister T.  SLAS Technol, 2020, 25(2), 190-199.