Publications

Kremling, V., Falke, S., Fernández-García, Y., et al. (2024). SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery. In Cold Spring Harbor Laboratory. DOI
Hammerschmidt, S. J., Barthels, F., Weldert, A. C., Kersten, C. (2024). Advanced Isothermal Titration Calorimetry for Medicinal Chemists with <i>ITCcalc</i>. JOURNAL OF CHEMICAL EDUCATION, 101(3), 1086-1095. DOI Author/Publisher URL
Arafet, K., Royo, S., Schirmeister, T., et al. (2023). Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L. ACS CATALYSIS, 13(9), 6289-6300. DOI Author/Publisher URL
Fernandez-de-la-Pradilla, A., Royo, S., Schirmeister, T., et al. (2023). Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L. ACS CATALYSIS, 13(20), 13354-13368. DOI Author/Publisher URL
Kallert, E., Behrendt, M., Frey, A., et al. (2023). Non-covalent dyes in microscale thermophoresis for studying RNA ligand interactions and modifications. CHEMICAL SCIENCE, 14(36), 9827-9837. DOI Author/Publisher URL
Kersten, C., Clower, S., Barthels, F. (2023). Hic Sunt Dracones: Molecular Docking in Uncharted Territories with Structures from AlphaFold2 and RoseTTAfold. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 63(7), 2218-2225. DOI Author/Publisher URL
Maus, H., Gellert, A., Englert, O. R., et al. (2023). Designing photoaffinity tool compounds for the investigation of the DENV NS2B-NS3 protease allosteric binding pocket. RSC MEDICINAL CHEMISTRY, 14(11), 2365-2379. DOI Author/Publisher URL
Maus, H., Hammerschmidt, S. J., Hinze, G., et al. (2023). The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and 19F NMR. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 258. DOI Author/Publisher URL
Maus, H., Mueller, P., Meta, M., et al. (2023). Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates. CHEMISTRY-A EUROPEAN JOURNAL, 29(50). DOI Author/Publisher URL
Barthels, F. (2022). Tools for the Design and Characterization of Covalent Cysteine Protease Inhibitors [PhD Thesis]. DOI Author/Publisher URL
Barthels, F., Hammerschmidt, S. J., Fischer, T. R., et al. (2022). A low-cost 3D-printable differential scanning fluorometer for protein and RNA melting experiments. HARDWAREX, 11. DOI Author/Publisher URL
Barthels, F., Meyr, J., Hammerschmidt, S. J., et al. (2022). 2-Sulfonylpyrimidines as Privileged Warheads for the Development of <i>S. aureus</i> Sortase A Inhibitors. FRONTIERS IN MOLECULAR BIOSCIENCES, 8. DOI Author/Publisher URL
Rudbari, H. A., Kordestani, N., Cuevas-Vicario, J. V., et al. (2022). Investigation of the influence of chirality and halogen atoms on the anticancer activity of enantiopure palladium(II) complexes derived from chiral amino-alcohol Schiff bases and 2-picolylamine. NEW JOURNAL OF CHEMISTRY, 46(14), 6470-6483. DOI Author/Publisher URL
Volynets, G. P., Barthels, F., Hammerschmidt, S. J., et al. (2022). Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening. JOURNAL OF ANTIBIOTICS, 75(6), 321-332. DOI Author/Publisher URL
Barthels, F., Schirmeister, T., Kersten, C. (2021). BANΔIT: B’-factor Analysis for Drug Design and Structural Biology. MOLECULAR INFORMATICS, 40(1). DOI Author/Publisher URL
Jung, S., Fuchs, N., Johe, P., et al. (2021). Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies. JOURNAL OF MEDICINAL CHEMISTRY, 64(16), 12322-12358. DOI Author/Publisher URL
Maus, H., Barthels, F., Hammerschmidt, S. J., et al. (2021). SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases. Bioorganic & Medicinal Chemistry, 47, 116392-116392.
Barthels, F., Barthels, U., Schwickert, M., Schirmeister, T. (2020). FINDUS: An Open-Source 3D Printable Liquid-Handling Workstation for Laboratory Automation in Life Sciences. SLAS TECHNOLOGY: Translating Life Sciences Innovation, 25, 190-199.
Barthels, F., Marincola, G., Marciniak, T., et al. (2020). Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of <i>Staphylococcus aureus</i> Sortase A. CHEMMEDCHEM, 15(10), 839-850. DOI Author/Publisher URL
Klein, P., Barthels, F., Johe, P., et al. (2020). Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics. MOLECULES, 25(9). DOI Author/Publisher URL
Klein, P., Johe, P., Wagner, A., et al. (2020). New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the <i>Trypanosoma</i> Protease Rhodesain. MOLECULES, 25(6). DOI Author/Publisher URL
Roman, D., Raguž L., Keiff, F., et al. (2020). Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives. Organic letters, 22, 3744-3748.
Millies, B., von Hammerstein, F., Gellert, A., et al. (2019). Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases. JOURNAL OF MEDICINAL CHEMISTRY, 62(24), 11359-11382. DOI Author/Publisher URL
Schmohl, L., Bierlmeier, J., von Kuegelgen, N., et al. (2017). Identification of sortase substrates by specificity profiling. BIOORGANIC & MEDICINAL CHEMISTRY, 25(18), 5002-5007. DOI Author/Publisher URL